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目的:观察骨膦(氯屈膦酸二钠、固令)对肿瘤骨转移引起的骨痛的治疗及不良反应。方法:骨膦(芬兰拉斯药厂生产)300 mg加入生理盐水500 ml缓慢静脉滴注4~5 h,连续5 d,每2周重复一次。结果:16例骨转移患者中显效3例,有效11例,总有效率81.3%,治疗中无明显不良反应。结论:骨膦治疗恶性肿瘤骨转移引起的骨痛效果肯定,作用平稳,持续时间长,无明显不良反应,耐受性好。
OBJECTIVE: To observe the treatment and side effects of bone phosphine (clodronate disodium and stupor) on bone pain caused by tumor bone metastasis. Methods: Bonephosphatidylcholine (manufactured by LasPharma Finnish) 300 mg was added to 500 ml of normal saline slowly by intravenous infusion for 4 ~ 5 h for 5 consecutive days and repeated every 2 weeks. Results: Among 16 patients with bone metastasis, 3 cases were markedly effective and 11 cases were effective. The total effective rate was 81.3%. There was no obvious adverse reaction in the treatment. CONCLUSION: Osteophor is effective in treating bone pain caused by bone metastasis of malignant tumor with stable effect, long duration, no obvious adverse reaction and good tolerance.