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目的观察替吉奥联合奥沙利铂化疗配合热疗治疗晚期胃癌的临床效果。方法选取医院收治的晚期胃癌患者60例为研究对象,随机分为A组和B组,每组30例。A组采用替吉奥联合奥沙利铂治疗;B组在A组的基础上采用热疗仪治疗。观察2组治疗总有效率与临床获益率、KPS评分及不良反应。结果 B组临床获益率为76.7%,高于A组的50.0%,差异有统计学意义(P<0.05);2组总有效率、总改善率及不良反应发生率比较差异均无统计学意义(P>0.05)。结论全身化疗联合局部热疗治疗晚期胃癌疗效肯定,临床获益率明显提高,不良反应少,耐受性好,值得临床推广应用。
Objective To observe the clinical effect of treatment of advanced gastric cancer by combining tegaserod and oxaliplatin combined with hyperthermia. Methods Sixty patients with advanced gastric cancer admitted to our hospital were selected as study subjects and randomly divided into A group and B group, with 30 cases in each group. Group A was treated with tiotropium combined with oxaliplatin; group B was treated with thermotherapy based on group A. The total effective rate and clinical benefit rate, KPS score and adverse reactions in the two groups were observed. Results The clinical benefit rate in group B was 76.7%, which was higher than that in group A (50.0%), the difference was statistically significant (P <0.05). There was no significant difference in the total effective rate, total improvement rate and adverse reaction rate between the two groups Significance (P> 0.05). Conclusion Systemic chemotherapy combined with local hyperthermia for the treatment of advanced gastric cancer is effective, the clinical benefit rate was significantly improved, fewer adverse reactions, well tolerated, worthy of clinical application.