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目的 观察双侧海马同时点燃时 ,是因破坏了点燃的拮抗作用而加速达到痫性发作 ,还是因点燃的拮抗作用的增强而延缓达到痫性发作。方法 按照Goddard方法将 2 0只成年Warster兔的双侧海马同时点燃 ,并与单侧海马点燃组作对照。结果 双侧海马同时点燃组 (BK)所有兔在平均 31次刺激后均出现 5期惊厥 ,8只兔显示有自发性痫性放电。在点燃早期 ,后放电 (AD)持续时间突然增加 ,此后逐渐增加。与单侧点燃 (UK)动物相比 ,双侧点燃法能显著提高动物点燃的成功率 (10 0 %对 5 5 % ,P <0 .0 1) ,但也显著减缓了点燃的进程 (31天 / 2 0天 ,P <0 .0 1)。结论 BK方法表现为神经元兴奋和抑制机制都增强。BK对点燃的致痫机制和筛选抗惊厥药物研究提供了一种更先进的复杂部分性癫痫动物模型。
Objective To observe whether the simultaneous firing of bilateral hippocampus accelerates the onset of seizures or the delayed onset of seizures due to the increased antagonism of ignition. Methods The bilateral hippocampus of 20 adult Warster rabbits were ignited by Goddard method and compared with unilateral hippocampal igniting group. Results All rabbits in both bilateral hippocampus (BK) groups had seizures of 5 after an average of 31 stimuli, and 8 rabbits showed spontaneous seizure discharge. In the early stage of ignition, the duration of post-discharge (AD) suddenly increased and then increased gradually. Bilateral ignition significantly increased the rate of successful litter firing (10% vs. 55%, P <0.01), but also significantly slowed the ignition process (31%) compared with unilateral litter (UK) animals Day / 20 days, P <0. Conclusions The BK method shows that the neuronal excitability and inhibition mechanisms are enhanced. BK provides a more sophisticated model of complex partial epilepsy in the study of the mechanism of ignition-induced epileptogenesis and screening of anticonvulsants.