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神经调节蛋白-1(neuregulin-1,NRG-1)是一类含有表皮生长因子样结构域的营养因子,其主要存在于神经组织,尤其是在神经元中含量丰富,集中在神经元的轴突、突触前膜和生长锥,胞体中含量较少。NRG-1也存在于神经胶质细胞,与突触可塑性、神经生长和再生密切相关。近年的研究表明,NRG-1对神经损伤后髓鞘的再生及修复发挥着重要的作用。本文主要对近年来NRG-1参与髓鞘再生及修复的研究进展作一综述。1 NRG-1及其ErbB受体信号通路1.1 NRG-1家族成员NRG是由NRG基因编码产物经选
Neuregulin-1 (NRG-1) is a type of trophic factor that contains an epidermal growth factor-like domain that is found mainly in nerve tissue, particularly in neurons, which is concentrated in the axis of neurons Sudden, presynaptic membrane and growth cone, less content in the cell body. NRG-1 is also present in glial cells and is closely related to synaptic plasticity, nerve growth and regeneration. Recent studies have shown that NRG-1 play an important role in the regeneration and repair of myelin after nerve injury. This review summarizes the research progress of NRG-1 in remyelination and repair in recent years. 1 NRG-1 and its ErbB receptor signaling pathway 1.1 NRG-1 family members NRG NRG gene encoding products by the election