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目的 :探讨P5 3、C -myc表达在胃癌发生、发展中的作用。方法 :对 6 0例胃癌、1 0例肠上皮化生组织和 1 0例对照组 ,应用免疫组化检测P5 3和C -myc基因蛋白。结果 :胃癌组的突变P5 3和C -myc基因表达均显著增高 (P >0 .0 1 ) ,而肠上皮化生组中P5 3和C -myc的表达与正常组无显著差异 (P >0 .0 5 ) ,肠上皮化生组的C -myc表达明显低于胃癌组 (P >0 .0 1 )。结论 :P5 3基因发生突变、失活以及C -myc基因激活 ,在胃癌的发生中可能起重要作用 ,检测C -myc基因蛋白表达有助于预测胃粘膜癌变
Objective: To investigate the role of P53 and C-myc expression in the development and progression of gastric cancer. Methods: P5 3 and C-myc gene proteins were detected by immunohistochemistry in 60 cases of gastric cancer, 10 cases of intestinal metaplasia and 10 cases of control group. RESULTS: The expression of mutant P53 and C-myc genes in gastric cancer group was significantly increased (P > 0.01), whereas the expression of P53 and C-myc in intestinal metaplasia group was not significantly different from that in normal group (P > 0. 05), C-myc expression in the intestinal metaplasia group was significantly lower than that in the gastric cancer group (P > 0. 01). Conclusion : The mutation and inactivation of P53 gene and the activation of C-myc gene may play an important role in the development of gastric cancer. The detection of C-myc gene protein expression is helpful to predict gastric canceration.