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野百合碱是中草药农吉利的有效成分。临床和实验资料都证明:野百合碱具有明显的抗癌作用。本文研究其对人体和动物癌细胞核酸生物合成的影响。结果证明:在八天内给予S_(180)瘤株鼠以野百合碱可降低瘤组织中RNA和DNA含量及其~(32)P掺入量。用~3H-UR和~3H-TdR掺入试验证明:野百合碱对~3H-UR掺入癌细胞RNA具有明显的抑制作用,而对~3H-TdR掺入癌细胞DNA的抑制作用则不明显。结果表明:野百合碱对癌细胞核酸生物合成的抑制作用主要表现在对癌细胞RNA生物合成的抑制作用。
Monocrotaline is an active ingredient of Chinese herbal medicine Nongli. Clinical and experimental data have shown that: Monocrotaline has a significant anti-cancer effect. This article investigates its effect on nucleic acid biosynthesis in human and animal cancer cells. The results showed that the administration of monocrotaline to S_(180) tumor-bearing mice within 8 days reduced RNA and DNA content and its ~(32)P incorporation in tumor tissues. The incorporation test of ~3H-UR and ~3H-TdR showed that monocrotaline significantly inhibited the incorporation of ~3H-UR into cancer cells, while the inhibition of ~3H-TdR incorporation into cancer cells was not. obvious. The results showed that the inhibitory effect of monocrotaline on the nucleic acid biosynthesis of cancer cells mainly reflected the inhibition of RNA biosynthesis in cancer cells.