由于ＬＰＳ在众多不同种属细菌中抗原性的差异，用单一或几种细菌的ＬＰＳ免疫小鼠所制备的抗ＬＰＳｍＡｂ存在着明显的交叉反应局限性，致使其在临床上ＬＰＳ的检测和内毒素血症的治疗中应用受到限制。因而，研制具有广泛交叉反应性的抗ＬＰＳｍＡｂ就具有非常重要的意义。脂 Due to the difference in antigenicity of LPS in many different species of bacteria, the anti-LPS mAbs prepared by immunization of mice with LPS alone or with several bacteria have significant cross-reaction limitations that have led to their clinical detection of LPS and endotoxin The application of blood treatment is limited. Therefore, the development of a wide cross-reactivity of anti-LPSmAb has a very important significance. fat