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目的 观察对直肠癌病人术前局部化疗的作用。方法 低位直肠癌病人16例,骶麻后扩肛,在肿瘤部位及周边多点注射5-氟脲嘧啶(5-FU)500mg,丝裂霉素(MMC)10mg,环磷酰胺(CTX)200mg,庆大霉素8万U,灭菌墨汁2～4ml。在直肠腔内应用5-FU 500mg,CTX 200mg,庆大霉素24万U,连用2天。注射后5天手术。结果 经病理检查,肿瘤局部均有变性、坏死。应用墨汁可以起到墨染淋巴结,使术中易于辨别及清扫淋巴结的作用。结论 直肠癌术前局部注射药物加直肠灌注化疗的方法疗效明显,副作用轻微,便于施术。
Objective To observe the effect of preoperative local chemotherapy on rectal cancer patients. Methods 16 patients with low rectal cancer were treated with anal expansion after ramie injection. 500 mg of 5-fluorouracil (5-FU), 10 mg of mitomycin (MMC) and 200 mg of cyclophosphamide (CTX) were injected into the tumor site and surrounding sites. , Gentamicin 80,000 U, Sterilized ink 2 ~ 4ml. In the rectal cavity, 5-FU 500 mg, CTX 200 mg, and Gentamicin 240,000 U were used for 2 days. 5 days after the injection. Results After pathological examination, the tumor had degeneration and necrosis. Application of ink can play a role in dyeing lymph nodes, making it easy to identify and clean lymph nodes during surgery. Conclusions Preoperative local injection of drugs plus rectal infusion chemotherapy is effective, with mild side effects and ease of operation.