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目的探讨2型糖尿病(type Ⅱ diabetes mellitus,T2DM)血清中血管内皮细胞生长因子(VEGF)与可溶性血管细胞黏附分子-1(sVCAM-1)的水平及其临床意义。结论采用双抗体夹心酶联免疫吸附法(ELISA)检测20例2型糖尿病患者和25例正常人血清VEGF与sVCAM-1水平。结果 2型糖尿病患者血清VEGF和sVCAM-1水平(389.64±54.60)pg/ml和(1443.87±422.33)ng/ml较正常对照组(100.60±22.81)pg/ml和(648.26±173.66)ng/ml明显升高(P<0.05)。结论 2型糖尿病患者血清VEGF、sVCAM-1含量增高,可能与2型糖尿病的发病机制有关。
Objective To investigate the serum levels of vascular endothelial growth factor (VEGF) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in type 2 diabetes mellitus (T2DM) patients and their clinical significance. Conclusion Serum levels of VEGF and sVCAM-1 were detected in 20 patients with type 2 diabetes mellitus and 25 normal subjects by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results Serum VEGF and sVCAM-1 levels (389.64 ± 54.60) pg / ml and (1443.87 ± 422.33) ng / ml in type 2 diabetic patients were significantly higher than those in normal controls (100.60 ± 22.81 pg / ml and (648.26 ± 173.66) ng / ml Was significantly higher (P <0.05). Conclusions Serum levels of VEGF and sVCAM-1 are increased in patients with type 2 diabetes mellitus, which may be related to the pathogenesis of type 2 diabetes mellitus.