关于铍病的发病机理,已有不少论据,证明铍和沽组织的互相作用,涉及到免疫因素的作用。De Nardi、Ordstrand等(1949)首先报导了患急性铍皮炎患者,身体的接触和未接触部位中皆存在对铍的变态反应。两年后Stener及Eisenbud提出自己的假说,认为以铍化合物作为抗原,可产生一种特异的抗体,使宿主致敏,从而使与铍接触的组织产生典型的炎症反应: 铍+蛋白质—→铍的特异抗原—→产生铍的特异抗体。进一步铍接触—→产生铍的 On the pathogenesis of beryllium disease, there are many arguments that beryllium and beu tissue interaction, involving the role of immune factors. De Nardi, Ordstrand et al. (1949) first reported that patients with acute beryllium dermatitis had beryllium allergies in both the body’s exposed and non-contacted parts. Two years later Stener and Eisenbud came up with their own hypothesis that using beryllium compounds as antigens produces a specific antibody that sensitizes the host and causes typical inflammatory reactions in the tissues contacted with beryllium: beryllium + protein -> beryllium Of the specific antigen - → beryllium-specific antibodies. Further beryllium contact - → produce beryllium