络合腙(complexan,亦作complexon)类化合物在有机分析试剂中占有重要的位置。而其中有一部分是利用Mannich反应合成的氨羧络合剂类金属指示剂。迄今为止,借Mannich反应合成的此类试剂已达数十种。这方面的研究始于五十年代初。Schwarzenbach首次借Mannich反应在邻甲酚酞分子中引入 Complexan (also complexon) compounds occupy an important position in organic analytical reagents. And part of them is the use of Mannich reaction synthesis of ammonia carboxylate complex metal indicator. To date, dozens of such reagents have been synthesized by the Mannich reaction. Research in this area began in the early 1950s. Schwarzenbach first introduced by Mannich reaction in o-cresolphthalein molecules