一、洋地黄的血中浓度和临床意义应用~3H 标记地高辛和放射免疫测定证明,地高辛的生物学半衰期为36小时,其在体内经过变化后大部分以原形从肾脏排泄。进一步证明,洋地黄在血中的浓度与心肌及其它组织间的浓度密切相关,Doherty 等人报告了人类心肌和血中地高辛浓度的比为30:1。因此,只要能测定血中地高辛的浓度,就可以推测其在心肌内的浓度,这在地高辛的治疗上是一个很 First, digitalis concentration in the blood and clinical significance ~ 3H labeled digoxin and radioimmunoassay proved that the biological half-life of digoxin 36 hours, most of its changes in the body after the prototype from the kidneys excretion. Further evidence that the concentration of digitalis in the blood is closely related to the concentration in myocardium and other tissues. Doherty et al. Reported a 30: 1 ratio of digoxin concentration in human myocardium and blood. Thus, as long as the concentration of digoxin in the blood can be measured, the concentration in the myocardium can be estimated, which is a very significant treatment of digoxin