溴化异丙阿托品(ipratropium bromide)系一抗胆碱能止喘药。现有文献报道,以该药10mg给11例窦性心动过缓病人口服,能显著提高心率,增加病人的心桩指数,还减少搏出容积。 以往临床上治疗窦性心动过缓,普遍使用硫酸阿托品或拟交感胺类药。前者增加窦性心动过缓作用虽比交感胺类药持久,但在治疗量也可引起持久的口于和视觉障碍等副作用。溴化异丙阿托品的毒副作用都比硫酸阿托品小,像前者的大鼠口服LD_(50)为622mg/kg,而后者的大鼠口服LD_(50)为1671mg/kg,对唾 Ipratropium bromide is an anticholinergic anticholinergic drug. The existing literature reports that the drug 10mg to 11 patients with sinus bradycardia oral administration, can significantly improve heart rate, increase the patient’s cardiac piles index, but also reduce stroke volume. In the past clinical treatment of sinus bradycardia, the general use of atropine sulfate or sympathomimetics. The former increased sinus bradycardia although longer than the sympathetic amines, but the amount of treatment can also cause persistent oral and visual impairment and other side effects. The toxic side effects of isopropylamine bromide are smaller than atropine sulfate, like the former oral LD_ (50) of 622mg / kg, while the latter’s oral LD_ (50) of 1671mg / kg,