论文部分内容阅读
本文介绍静注青霉素治疗重症钩端螺旋体病(下称钩体病)的疗效。受试对象为重度(血清肌酸酐177μmol/L)和晚期(住院前病程>4天)钩体病患者42例。入院时无尿、有其他疾病、精神错乱或昏迷者不列为受试对象。受试者以随机双盲法分为两组:(1)治疗组23例,入院前病程为9±2.9天,以青霉素150万单位,每6小时1次,静注,共7天;(2)对照组19例,入院前病程为9±2.4天,以等量生理盐水静注。出院标准为:完成全疗程28次注射;至少48小时体温<37.6℃和血清肌酸酐正常。出院后1周及1个月各随访一次。
This article describes the efficacy of intravenous penicillin in the treatment of severe leptospirosis (Leptospirosis). The subjects were severe (serum creatinine 177μmol / L) and advanced (pre-hospital duration> 4 days) leptospirosis in 42 patients. No urine on admission, other illnesses, insanity or coma were not included as subjects. Subjects were randomly divided into two groups: (1) the treatment group, 23 cases, pre-admission course of 9 ± 2.9 days to 1.5 million units of penicillin, once every 6 hours, intravenous injection, a total of 7 days; ( 2) The control group of 19 patients, pre-admission course of 9 ± 2.4 days, an equal amount of normal saline intravenously. Discharge criteria: complete the whole course of 28 injections; at least 48 hours body temperature <37.6 ° C and serum creatinine normal. One week after discharge and one month after each visit.