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新生儿糖尿病(NDM)与1型糖尿病不同(不具有典型的人白细胞抗原类型,也未见自身免疫学指标),它分为暂时性糖尿病(TNDM)和永久性糖尿病(PNDM)二类。前者是由父源6号染色体异常所致,而后者则是基因突变致胰岛发育不全引起。TNDM虽用胰岛素一年内可以治愈,但有60%在青春期复发;PNDM是终身疾病。
Neonatal diabetes mellitus (NDM) is different from type 1 diabetes mellitus (not having a typical human leukocyte antigen type and no autoimmune criteria) and is classified into two categories, transient diabetes mellitus (TNDM) and permanent diabetes mellitus (PNDM). The former is caused by the abnormality of paternal-derived chromosome 6, while the latter is caused by gene mutation caused by islet hypoplasia. Although TNDM can be cured within one year with insulin, 60% recurrent in adolescence; PNDM is a lifelong disease.