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背景:该研究旨在评价在现有的冠状动脉粥样硬化的病变中,遗传因素对粥样硬化斑块进展及特异性心肌梗死是否存在显著作用。方法:对欧洲后裔参与者冠状动脉造影表型进行了两项全基因组关联研究(GWAS),为寻找冠状动脉疾病(CAD)易感性基因位点,研究比较了有异常(n=12393)和无异常的(对照组n=7383)个体;为寻找心肌梗死易感性基因位点,也同时比较了造影证实存在CAD并且有心肌梗死的个体(n=5783)与虽有CAD但无心肌梗死的个体(n=3644)。
BACKGROUND: This study was designed to evaluate whether genetic factors have a significant effect on the progression of atherosclerotic plaques and specific myocardial infarction in current coronary atherosclerotic lesions. METHODS: Two genome-wide association studies (GWAS) were performed on coronary angiography phenotypes in European descent participants. In order to find coronary artery disease (CAD) susceptibility loci, we compared the presence of abnormalities (n = 12393) (Control group, n = 7383). To find myocardial infarction susceptibility loci, individuals with CAD and myocardial infarction at angiography (n = 5783) and those with CAD but no myocardial infarction (n = 3644).