对25例进展期胃肠道恶性肿瘤患者手术前后采用腹腔内热灌注化疗。灌注前后肝、肾功能正常。结果:患者白细胞、红细胞及血小板计数在灌注后第2~3周下降明显,但第4周后开始回升。随访近2年,2例分别于术后6和9个月死亡,余23例未发现肿瘤复发和转移。作者认为腹腔内化疗简单易行,毒副作用小,但在给药时间及药物剂量方面有必要进行前瞻性研究。 Twenty-five patients with advanced gastrointestinal malignancy were treated with intraperitoneal hyperthermic perfusion chemotherapy before and after surgery. Liver and kidney functions were normal before and after perfusion. RESULTS: The leukocyte, red blood cell, and platelet counts decreased significantly in the second to third weeks after infusion, but began to rebound after the fourth week. During the follow-up period of 2 years, 2 cases died at 6 and 9 months after operation, and the remaining 23 cases had no recurrence or metastasis. The authors believe that intraperitoneal chemotherapy is simple and easy, with little side effects, but there is a need for prospective studies in terms of administration time and drug dose.