以炔基溴和咪唑衍生物为反应原料,详细探讨了无过渡金属催化条件下的咪唑类芳香炔胺化合物的合成方法.研究结果表明,以N,N-二甲基甲酰胺为溶剂、碳酸钾为碱,于80℃下反应12 h即可获得中等偏上收率的碳-氮偶联产物.通过上述方法合成得到了系列芳香炔胺衍生物,其结构经1H NMR和13C NMR表征. The synthesis method of imidazoles aromatic alkyne amines without transition metal catalysis was discussed in detail by using alkynyl bromine and imidazole derivatives as raw materials.The results showed that with N, N-dimethylformamide as solvent, Potassium was used as base and reacted at 80 ℃ for 12 h to obtain middle-yield carbon-nitrogen coupling products. A series of aromatic alkynylamine derivatives were synthesized by the above method. Their structures were characterized by 1H NMR and 13C NMR.