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槲皮素及其衍生物既是膳食成分中最常见的类黄酮物质之一,也是一些中草药的有效成分,具有抗肿瘤、抗血小板聚集、抗氧化、保护心血管功能等多种生物活性,临床已有应用。近年实验研究表明,槲皮素还具有显著的抗纤维化作用,且无明显副作用,其作用机制主要包括抑制成纤维细胞增殖和胶原合成以及阻止氧化损伤等,能够有效抑制肝硬化,抑制肾脏、心肌等器官和组织纤维化的病理过程。
Quercetin and its derivatives are not only one of the most common flavonoids in dietary ingredients, but also an effective ingredient of some Chinese herbal medicines. They have many biological activities such as anti-tumor, anti-platelet aggregation, anti-oxidation, cardiovascular protection, etc. There is application. In recent years, experimental studies have shown that quercetin also has significant antifibrotic effects and no obvious side effects. Its mechanism of action mainly includes the inhibition of fibroblast proliferation and collagen synthesis and the prevention of oxidative damage. It can effectively inhibit cirrhosis and inhibit the kidneys. The pathological process of myocardial and other organ and tissue fibrosis.