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目的调查75g 口服葡萄糖耐量试验(OGTT)诊断糖代谢异常的重复性。方法 259例既往未诊断糖尿病的受试人群(男152例,女107例)间隔2～3周重复进行两次 OGTT。结果OGTT 总体重复率为56.4%。根据第一次 OGTT 结果把人群分为糖耐量正常、糖调节受损(IGR)和糖尿病3组,其重复率分别为91.2%、37.5%和63.8%,组间比较差异有统计学意义(P<0.05)。根据人群所含的代谢异常组分个数的不同分组,发现具有2个代谢异常组分的人群 OGTT 重复率明显低于代谢异常组分小于或大于2个的人群(P 值均<0.05)。两次 OGTT 结果为正常-异常组的年龄、血压、心率和腰臀围比明显高于正常-正常组(P 值均<0.05),异常-异常组的腰围和 TG 高于、HDL-C 低于正常-异常组,其他临床特征差异无统计学意义。结论 OGTT 总体重复率较低,在 IGR 人群和中度代谢异常人群中尤为显著。与正常人群相比,只要一次 OGTT 显示为异常的人群就具有较多的心血管病危险因子,因此虽然 OGTT 重复性较低,但是对糖代谢异常的筛查仍具有重要的实践意义。
Objective To investigate the repeatability of oral glucose tolerance test (OGTT) in the diagnosis of abnormal glucose metabolism. Methods A total of 259 patients with undiagnosed diabetes mellitus (152 males and 107 females) were randomized to receive OGTT twice a week for 2 to 3 weeks. Results The overall OGTT repetition rate was 56.4%. According to the results of the first OGTT, the population was divided into three groups: normal glucose tolerance, impaired glucose regulation (IGR) and diabetes mellitus (91.2%, 37.5% and 63.8%, respectively), and the difference was statistically significant <0.05). According to the different groups of metabolic abnormalities contained in the population, it was found that the repetitive rate of OGTT was significantly lower in those with two metabolic abnormalities than those with metabolic abnormalities less than or greater than two (all P <0.05). The results of two OGTT were normal-abnormal group were significantly higher than those in normal-normal group (P <0.05), waist circumference and TG were higher than those in abnormal-abnormal group, HDL-C was lower There was no significant difference in other clinical features between normal and abnormal group. Conclusion The overall OGTT repetition rate is low, especially in IGR population and moderate metabolic abnormality population. Compared with the normal population, as long as a group of people with OGTT abnormalities have more risk factors for cardiovascular disease, although OGTT low repeatability, but screening for abnormal glucose metabolism is still of important practical significance.