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铜绿假单胞菌(PA)是一种重要的条件致病菌,现已成为临床标本中分离出的常见菌。由铜绿假单胞菌所造成的感染中形成生物被膜(BF)是极为常见的现象,BF对抗生素的耐药性明显增加并难以被彻底清除,由此造成的慢性反复感染已经成为临床上治疗的难题,所以研究铜绿假单胞菌BF的耐药机制,对于临床治疗BF导致的慢性反复感染有极其重要的意义。
Pseudomonas aeruginosa (PA) is an important opportunistic pathogen that has now become a common bacterium isolated from clinical specimens. The formation of biofilm (BF) in an infection caused by Pseudomonas aeruginosa is extremely common, and BF has a marked increase in resistance to antibiotics and is difficult to remove completely, and the resulting chronic recurrent infections have become clinically relevant Therefore, studying the mechanism of drug resistance of Pseudomonas aeruginosa BF is of extremely important significance for the clinical treatment of chronic recurrent infections caused by BF.