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目的 定量分析伴神经内分泌（NE）分化的乳腺癌细胞DNA含量及其意义。rn方法 我们采用自行设计的MIPS-Ⅲ型图像分析仪对17例NE(+)的乳腺癌和64例NE(-)的乳腺癌癌细胞核DNA含量、核面积等9项参数进行测量。rn结果 81例乳腺癌中，NE细胞(+)组17例，NE细胞(-)组64例，NE细胞(+)乳腺癌组积分吸光度，平均吸光度、DNA指数、DNA主干系峰值、>5c异倍体细胞数以及异倍体率显著低于NE细胞(-)组乳腺癌（P均<0.01）。在Ⅰ-Ⅱ级与Ⅲ级乳腺癌中，NE细胞阳性率分别为32.5%与7.9%，两者有显著差异（P5c aneuploidy cells and the rate of aneuploidy cells were all lower than those in the NE negative breast carcinoma cases (P<0.01). The positive rates of NE cells were 32.5% and 7.9% in grade Ⅰ-Ⅱ breast carcinomas and in grade Ⅲ breast carcinomas respectively with significant difference between the two groups (P<0.01).Conclusion Our study shows that NE (+) breast carcinomas have lower DNA parameters than NE (-) breast carcinomas, suggesting that NE (+) breast carcinomas have lower malignancy.