论文部分内容阅读
研究8－MOP与ATRA单独及联合应用时Mc3细胞周期的影响。方法：流式细胞仪测定细胞DNA含量，Multicycle软件分析细胞周期分布情况。结果：Mc3细胞经IC30的8－MOP与ATRA单色及联合处理5天以后，实验组均表现为G1／G0期细胞增加，G2＋M或细胞减少，S期细胞变化不规律。结论：8－MOP与ATRA单独及联合作用可抑制Mc3细胞有丝分裂。
To investigate the effect of 8-MOP and ATRA alone and in combination on Mc3 cell cycle. Methods: The cell DNA content was determined by flow cytometry. Multicycle software was used to analyze the cell cycle distribution. Results: After treated with IC30 monochromatic 8-MOP and ATRA for 5 days, the number of cells in G1 / G0 phase increased, the number of G2 + M cells decreased, and the S phase cells changed irregularly. Conclusion: 8-MOP alone and in combination with ATRA can inhibit the mitosis of Mc3 cells.