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目的通过分析我院内科细菌学数据及临床控制使用抗菌药物的效果,探索实施抗菌药物合理使用方案的可行性。方法采用回顾性分析方法采集2007和2008年病原菌分布情况和药敏数据,将两年数据进行对比分析。结果革兰阴性菌菌株数2008年较2007年有明显的下降,各细菌耐药率也有不同程度的下降,特别是大肠埃希菌耐药率下降明显,但铜绿色假单胞菌对二代和四代头抱菌素耐药率有一定的上升;革兰阳性菌中金黄色葡萄球菌菌株数明显下降,但表皮葡萄球菌有明显上升;表皮葡萄球菌、金黄色葡萄球菌耐药率2008年较2007年有较明显下降。结论加强临床抗菌药物管理能明显降低临床感染发生率和细菌耐药性;具有重大的临床意义。
Objective To analyze the feasibility of antibacterial drug rational use by analyzing the bacteriological data of our hospital and the effect of clinical use of antibacterials. Methods The distribution of pathogenic bacteria and drug susceptibility data in 2007 and 2008 were collected by retrospective analysis. The data of two years were compared and analyzed. Results The number of Gram-negative bacteria in 2008 decreased significantly compared with that in 2007, and the rates of bacterial resistance decreased. In particular, the resistance rate of Escherichia coli decreased significantly, but Pseudomonas aeruginosa had no effect on the second generation And four generations of cephalosporins resistance rate has a certain increase; Gram-positive bacteria Staphylococcus aureus strains significantly decreased, but Staphylococcus epidermidis increased significantly; Staphylococcus epidermidis, Staphylococcus aureus resistance rate in 2008 Compared with 2007, there is a clear drop. Conclusion To strengthen the management of clinical antimicrobial agents can significantly reduce the incidence of clinical infection and bacterial resistance; has great clinical significance.