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自上世纪90年代开始,促性腺激素释放激素激动剂(gonadotropin-releasing hormone agonist,GnRH-a)被广泛用于辅助生育技术领域控制性超排卵治疗中。近年来,人们逐渐认识到 GnRH-a 在提高获卵数量和妊娠率的同时,存在着对垂体和卵巢黄体的过度抑制作用。前期研究显示,在不同剂量 GnRH-a 降调节方案中,启动日血清黄体生成素(LH)、雌二醇水平以及人绒毛膜促性腺激素(hCG)注射日的 LH、雌二醇、孕酮水平存在差异。本研究针对这一现象,通过对 GnRH-a 降调节的体外受精一胚胎移植(in vitro fertilizationand embryo transfer,IVF-ET)周期中卵巢黄素化颗粒细胞甾体激素合成的关键性调节蛋白——甾体激素合成急性调节
Since the 1990s, gonadotropin-releasing hormone agonist (GnRH-a) has been widely used in controlled ovulation induction in assisted reproductive technology. In recent years, people gradually realized that GnRH-a in increasing the number of oocytes and pregnancy rate, while there is excessive inhibition of pituitary and ovarian corpus luteum. In previous studies, LH regimen, estradiol level, and LH, estradiol and progesterone levels on the day of initiation of human chorionic gonadotropin (hCG) There are differences in level. In this study, we investigated the effect of GnRH-a on steroid-steroid synthesis, a key regulator of steroid hormone synthesis in ovarian luteinized granulosa cells during the in vitro fertilization and embryo transfer (IVF-ET) Acute hormonal synthesis