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发生卵巢过度刺激综合征(OHSS)的病理生理机制尚不清。主要表现为卵巢增大伴有多囊及间质水肿和毛细血管通透性增加使体液迅速转移到血管外。后者是与该综合征相关的主要病死原因。毛细血管通透性增加使体液进入第三间隙,导致低血容量、腹水和电解质平衡紊乱。有人认为,毛细血管通透性改变受到来源于卵巢的血管活性物质调节。这种卵巢因子是在应用hCG后由黄体分泌的。前列腺素、组织胺、血清素、泌乳素及其它多种肽类物质被认为可能是导致毛细血管通透性增加的卵巢因子,在卵
The pathogenesis of ovarian hyperstimulation syndrome (OHSS) is not clear. Mainly for the enlargement of the ovary accompanied by polycystic and interstitial edema and increased capillary permeability to the rapid transfer of body fluids outside the blood vessels. The latter is the main cause of death associated with the syndrome. Increased capillary permeability causes the body fluid to enter the third space, resulting in hypovolemia, disturbed ascites and electrolyte imbalance. Some people think that changes in capillary permeability by ovarian derived vasoactive substances regulation. This ovarian factor is secreted by the corpus luteum after hCG administration. Prostaglandins, histamine, serotonin, prolactin, and many other peptidic substances are thought to be likely to be an ovarian factor that leads to increased capillary permeability.