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目的:观察热毒宁注射液对比静脉用甲泼尼龙治疗支气管哮喘急性发作患者的临床疗效和安全性。方法:将68例住院的哮喘急性发作患者随机分为治疗组和对照组,治疗组给予热毒宁注射液20 mL,对照组予以甲泼尼龙注射液40 mg,分别加入生理盐水230 mL中静脉滴注,1次/d,疗程为7～10 d。观察两组患者的临床疗效、症状改善、血象、血气及肺功能各项指标的变化情况。结果:两组临床疗效无统计学差异;药物不良反应发生率,治疗组明显低于对照组。结论:热毒宁辅助治疗支气管哮喘急性发作患者临床症状改善明显,效果良好,值得临床推广应用。
Objective: To observe the clinical efficacy and safety of Renduining injection in comparison with intravenous methylprednisolone in patients with acute exacerbation of bronchial asthma. Methods: Sixty-eight patients with acute exacerbation of asthma were randomly divided into treatment group and control group. The treatment group was treated with injection of Renduining 20 mL, the control group with methylprednisolone injection 40 mg, and the medium with 230 mL of medium saline Instillation, 1 / d, treatment for 7 ~ 10 d. The clinical curative effect, symptom improvement, blood, blood gas and pulmonary function indexes of two groups were observed. Results: There was no significant difference in clinical efficacy between the two groups. The incidence of adverse drug reactions in the treatment group was significantly lower than that in the control group. Conclusions: The clinical efficacy of Radix Ninin in the treatment of acute exacerbation of bronchial asthma is obviously improved with good effect, which is worthy of clinical application.