论文部分内容阅读
调节性T细胞(Tregs)特征性表达FOXP3,FOXP3与Tregs发育和功能密切相关。近年来发现Tregs功能异常在哮喘发病过程中具有重要作用,诱导FOXP3表达是糖皮质激素和特异性免疫治疗缓解哮喘作用机制之一。FOXP3是哮喘的发病机制和治疗研究中的又一个潜在热点。
Regulatory T cells (Tregs) characteristic expression of FOXP3, FOXP3 and Tregs development and function are closely related. In recent years, it was found that Tregs dysfunction plays an important role in the pathogenesis of asthma. Induction of FOXP3 expression is one of the mechanisms of glucocorticoid and specific immunotherapy to alleviate asthma. FOXP3 is another potential hotspot in the pathogenesis and treatment of asthma.