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目的:润肠通便方预防托烷司琼相关便秘的疗效及不良反应的观察。方法:将60例患者,随机分为2组,各30例。对照组给予化疗加注射用盐酸托烷司琼;治疗组在对照组治疗基础上加用润肠通便方;比较2组患者便秘的发生率以及药物的不良反应。结果:治疗组便秘发生率6.67%,发生平均时间是70.5 h;对照组便秘发生率36.67%,便秘发生的平均时间是23.3 h。2组便秘的发生率以及发生时间比较,差异均有统计学意义(P<0.05)。治疗组呕吐发生率20.00%,3~4级各有1例;骨髓抑制发生率16.67%,3~4级发生为0;肝肾功能检查、尿便常规及心电图检查3~4级发生为0。对照组呕吐发生率43.33%,3~4级发生1例;骨髓抑制发生率16.67%,3~4级发生为0;肝肾功能检查、尿便常规及心电图检查3~4级发生为0。结论:润肠通便方对预防盐酸托烷司琼引起的便秘等副反应,有良好的预防作用和安全性,临床上值得推广应用。
Objective: To observe the curative effect and adverse reaction of relieving catharsis and constipation related to constipation. Methods: 60 patients were randomly divided into two groups, each 30 cases. The control group was given chemotherapy plus injection of tropisetron; treatment group in the control group based on the addition of laxative side; the incidence of constipation and adverse drug reactions in two groups were compared. Results: The incidence of constipation in treatment group was 6.67%, the average time was 70.5 h, the incidence of constipation in control group was 36.67%, and the average time for constipation was 23.3 h. The incidence of constipation and the occurrence time of the two groups were significantly different (P <0.05). The incidence of vomiting was 20.00% in the treatment group and 1 in the grade 3 to 4 respectively. The incidence of bone marrow suppression was 16.67%, which was 0 in grade 3 to 4. The liver and kidney function tests, routine urination and electrocardiogram grade 3 to 4 were 0 . The incidence of vomiting was 43.33% in the control group, 1 case was in grade 3 to 4, the incidence of bone marrow suppression was 16.67%, and the grade 3 to 4 was 0. Liver and kidney function tests, urine routine examination and electrocardiogram grade 3-4 occurred as 0. Conclusion: Runchang Tongbian decoction on the prevention of side effects caused by constipation and other side effects, has a good preventive effect and safety, it is worth promoting the clinical application.