目的探讨抗结核药诱发肝损害的发病情况及特点。方法回顾分析近10年来496例结核病在使用抗结核药中诱发的72例(14.52%)肝损害的临床资料,观察与分析肝损害情况。结果该组肝损害治愈缓解率达94.44%(68/72)、死亡率5.56%(4/72)。72例肝损害中有肝炎病史者占52.78%(38/72)。结论抗结核药物诱发肝损害应引起重视,对有肝炎病史者选用抗结核药时要慎重。 Objective To investigate the incidence and characteristics of anti-TB drugs induced liver damage. Methods The clinical data of 72 cases (14.52%) of liver damage induced by anti-tuberculosis drugs in 496 cases of tuberculosis in recent 10 years were retrospectively analyzed. The liver damage was observed and analyzed. Results The cure rate of liver damage in this group was 94.44% (68/72), the mortality rate was 5.56% (4/72). 72 cases of liver damage in the history of hepatitis accounted for 52.78% (38/72). Conclusion Anti-TB drug-induced liver damage should pay attention to the history of hepatitis selected anti-TB drugs should be careful.