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目的探讨前列地尔(凯时)对糖尿病肾病患者肾功能不全早期肾内动脉血流变化的影响及彩色多普勒超声的应用价值。方法以30例正常人为对照组,50例经临床确诊的2型糖尿病肾病肾功能不全早期的患者为凯时治疗组。应用彩色多普勒超声对治疗组患者的肾窦部段动脉(SRA)、叶间动脉(IRA)和肾弓形动脉(ARA)进行检查,观察血流的收缩期最大血流速度(Vsmax)、舒张期最低血流速度(Vdmin)和阻力指数(RI)。结果与对照组比较,治疗组用药前SRA、ARA、IRA的Vsmax、Vdmin明显减少,RI值明显升高(P<0.05);用药后SRA的Vsmax明显增加(P<0.05),SRA、ARA的Vdmin明显增加(P<0.05),RI值明显降低(P<0.05)。结论彩色多普勒超声对判断糖尿病肾病肾功能不全有一定价值,凯时注射液对糖尿病患者肾功能不全早期肾内动脉血流改善有积极的作用,RI可作为评价凯时注射液疗效的敏感指标。
Objective To investigate the effect of alprostadil on the changes of early renal arterial blood flow in patients with diabetic nephropathy with renal insufficiency and the application value of color Doppler ultrasound. Methods 30 cases of normal control group, 50 cases of clinically diagnosed type 2 diabetic nephropathy in patients with renal insufficiency early Kai treatment group. Color Doppler ultrasound was used to examine the segmental renal artery (SRA), the interlobar artery (IRA) and the renal arcuate artery (ARA) in the treatment group. The maximum systolic blood flow velocity (Vsmax) Diastolic minimum blood flow velocity (Vdmin) and resistance index (RI). Results Compared with the control group, the Vsmax and Vdmin of SRA, ARA and IRA in the treatment group decreased significantly and the RI value increased significantly (P <0.05). The Vsmax of SRA increased significantly (P <0.05) Vdmin increased significantly (P <0.05), RI value decreased significantly (P <0.05). Conclusions Color Doppler ultrasound has some value in judging renal insufficiency of diabetic nephropathy. Ketous injection has a positive effect on the improvement of early renal artery blood flow in patients with renal insufficiency due to renal insufficiency. RI can be used as a sensitive index to evaluate the curative effect of Kaishi injection index.