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本文参用Velaskar血小板聚集性检查方法研究了654-2对内毒素血症狗肺解聚微聚物功能的影响。结果表明:654-2能保护内毒素血症狗的肺解聚功能,解聚血中的微聚物和减轻内毒素血症早期的低血压和通气障碍。提示654-2治疗感染性休克、ARDS等症,可能与保护肺非呼吸功能有关。
In this paper, the effect of 654-2 on the function of lung depolymerization micro-polymers in endotoxemia dogs was studied using Velaskar platelet aggregation assay. The results showed that 654-2 can protect the lungs from detoxification in dogs with endotoxemia, depolymerize micromolecules in blood, and reduce early hypotension and ventilatory disturbances in endotoxemia. Tip 654-2 treatment of septic shock, ARDS embolism may be related to the protection of lung non-respiratory function.