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对３５例梗阻性黄疸（梗黄）患者和２０例正常人外周血单核细胞（ＰＢＭＣ）的ｍＩＬ─２Ｒ和ｓＩＬ─２Ｒ检测。结果发现梗黄患者ＰＢＭＣ经植物血凝素（ＰＨＡ）刺激及７２小时培养，ｍＩＬ─２Ｒ表达显著低于正常对照组（Ｐ＜０．００１），而血清３ＩＬ─２Ｒ水平则显著高于对照组（Ｐ＜０．０１），上述变化程度与梗黄类型密切相关，梗黄患者ｓＩＬ─２Ｒ水平与血清胆红素浓度及梗阻时限显著正相关（ｒ＝０．６０５Ｐ＜０．０１；ｒ＝０．５２０，Ｐ＜０．０１），相反ｍＩＬ─２Ｒ则与上述二者无关。我们认为这种免疫调控紊乱与梗黄患者感染易感性高有关。提示：检测血清ｓＩＬ─２Ｒ对不同梗黄类型、梗阻程度、梗阻时限患者的免疫壮态的评估有重要意义，且具有简便、快速、无创性等优点。
35 cases of obstructive jaundice (yellow) and 20 cases of normal peripheral blood mononuclear cells (PBMC) of the mIL ─ 2R and sIL ─ 2R detection. The results showed that, PBMCs were significantly lower than those of normal control group (P <0.001), while the level of serum 3IL-2R was significantly higher than that of control group (P <0.01). The degree of change was closely related to the type of the stems. The level of sIL-2R in the patients with stool was positively correlated with serum bilirubin concentration and obstruction time (r = 0.605 P <0.01; r = 0.520, P <0.01). On the contrary, mIL-2R was unrelated to the above two. We think this disorder of immune regulation is associated with a high susceptibility to infection in patients with the disease. It is indicated that the detection of serum sIL-2R is of great significance for the assessment of the immune status of patients with different types of stem, degree of obstruction and obstruction time, and has the advantages of simple, rapid and noninvasive.