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目的分析肺结核患者化疗不良反应原因,探索有效应对方案。方法对文成县2010年7月1日—2011年6月30日登记治疗的182例肺结核患者进行随访和跟踪调查,查阅患者治疗档案,并进行分析。结果 182例肺结核患者的抗结核药物不良反应总发生率为35.16%,其中肝损害发生率10.99%,胃肠道反应发生率7.14%。87.50%的不良反应发生在治疗开始的前4周,严重不良反应占12.50%。合并其他疾病和采用2H3R3Z3E3/4H3R3隔日间歇疗法是肺结核不良反应的危险因素,OR值分别为2.386和2.578。结论合并其他疾病和采用2H3R3Z3E3/4H3R3隔日间歇疗法是引起肺结核药物不良反应的主要原因。
Objective To analyze the causes of chemotherapy-induced adverse reactions in patients with pulmonary tuberculosis and to explore effective countermeasures. Methods A total of 182 pulmonary tuberculosis cases registered and treated in Wencheng County from July 1, 2010 to June 30, 2011 were followed up and followed up. The patient treatment files were reviewed and analyzed. Results The total incidence of adverse reactions of anti-tuberculosis drugs in 182 patients with tuberculosis was 35.16%. The incidence of liver damage was 10.99% and the incidence of gastrointestinal reactions was 7.14%. 87.50% of the adverse reactions occurred in the first 4 weeks of treatment, serious adverse reactions accounted for 12.50%. Combined with other diseases and the use of 2H3R3Z3E3 / 4H3R3 every other day intermittent therapy is a risk factor for adverse reactions of tuberculosis, OR values were 2.386 and 2.578. Conclusions Combination of other diseases and the use of 2H3R3Z3E3 / 4H3R3 every other day intermittent therapy is the main reason for the adverse reactions of tuberculosis drugs.