阐述了胰岛素刺激葡萄糖转运的信号机制 ,在受体和受体后水平胰岛素信号转导缺陷与胰岛素抵抗 (IR)的关系。已有的研究提示 ,IR很可能是在一些遗传性缺陷的基础上 ,加上环境应激的作用而产生的复杂表型。还有可能是胰岛素信号转导和效应系统并不存在分子缺陷 ,只是一些关键的信号分子功能处于正常低水平 ,导致信号转导能力减弱 The signal mechanism of insulin-stimulated glucose transport is elucidated at the receptor and receptor level following insulin signaling deficiencies and insulin resistance (IR). Previous studies have suggested that IR is likely to be a complex phenotype resulting from the combination of environmental stress and some genetic defects. It is also possible that there is no molecular defect in the insulin signaling and effector systems, but that some of the key signaling molecules function at a normal low level, resulting in weakened signal transduction