非甾体抗炎药的发展吡唑酮类非甾抗炎药系19世纪末直接由水杨酸盐衍变来的,与合成水杨酸盐同步发展。事实上,在阿斯匹林问世之前,最早的吡唑酮类药物——安替比林和氨基比林已十分畅销。它们最初是作为退热药被引用的,后来,很快就用来治疗风湿病和轻微的疼痛。广泛的应用终于认识到其罕见但却严重的副作用——粒细胞缺乏症。这就导致人们去寻找更安全的吡唑酮类药物。第二次世界大战后,开始引用保泰松及其有效的代谢产物——羟基保泰松。这两种药物均具优良的 The development of non-steroidal anti-inflammatory drugs Pyrazolidone non-steroidal anti-inflammatory drugs directly from the late 19th century salicylate derived, and the simultaneous development of synthetic salicylates. In fact, the first pyrazole-type drugs, antipyrine and aminopyrine, were already very popular before the advent of aspirin. They were originally quoted as antipyretics, and later quickly used to treat rheumatism and minor pain. A wide range of applications have finally realized its rare but serious side effect, agranulocytosis. This led people to search for safer pyrazolones. After World War II, began to quote Phenylbutazone and its effective metabolite - hydroxy phenylbutazone. Both drugs are excellent