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4’-溴甲基-2-联苯甲酸叔丁酯(1)是合成抗高血压药替米沙坦(telmisartan)的中间体,通常以4’-甲基-2-氰基联苯为原料,经水解、酯化得4’-甲基-2-联苯甲酸叔丁酯(2),再经溴化反应制得。文献中的溴化反应主要采用1,3-二溴-5,5-二甲基海因(DBDMH)或N-溴代丁二酰亚胺(NBS)为
Tert-Butyl 4’-bromomethyl-2-dibenzoate (1) is an intermediate for the synthesis of the anti-hypertensive drug telmisartan and is usually prepared using 4’-methyl-2-cyanobiphenyl Raw materials, hydrolysis, esterification 4’-methyl-2-diphenylic acid tert-butyl ester (2), and then brominated in the system. The bromination reaction in the literature mainly uses 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) or N-bromosuccinimide (NBS) as