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目的探讨两面针外用对豚鼠口腔溃疡模型的影响。方法用苯酚溶液灼烧豚鼠面颊造成口腔溃疡模型,观察两面针水煎液高、中、低剂量和两面针糊剂高、低剂量对豚鼠口腔溃疡模型水肿溃疡程度、溃疡面积及局部病理学的影响。结果苯酚溶液可成功复制豚鼠口腔溃疡模型。与模型组比较,两面针水煎液高、中、低剂量和两面针糊剂高、低剂量均可明显减轻豚鼠口腔溃疡局部症状(P<0.05),显著缩小口腔溃疡面积(P<0.01),并可明显减轻溃疡局部病理变化(P<0.01)。结论两面针外用对豚鼠口腔溃疡有较好的疗效。
Objective To investigate the effects of topical two-needle acupuncture on guinea pig oral ulcer model. Methods The buccal cavity ulcer model was induced by the phenol solution on the cheek of guinea pigs. The edema ulcer, ulcer area and pathology of guinea pig oral ulcer model were observed under high, medium and low dose of two-needle decoction and high and low dose of two- influences. Results Phenol solution successfully replicated guinea pig oral ulcer model. Compared with the model group, the high, medium and low doses of the two-way decoction decoction and the high and low doses of the two-sided acupuncture can significantly reduce the local symptoms of oral ulcer in guinea pigs (P <0.05) and significantly reduce the area of oral ulcers (P0.01) , And can significantly reduce the local pathological changes of ulcer (P <0.01). Conclusion Both sides needles have good curative effect on guinea pig oral ulcer.