论文部分内容阅读
液体活检通过分析外周血中循环肿瘤细胞(CTC)和循环肿瘤核酸(ctDNA、microRNA)基因的表达和变异,从而获取肿瘤发生、转移和治疗的信息,在肿瘤的精准治疗中具有广阔的应用前景。发展有效的CTC、ctDNA及microRNA的检测仪器显得尤为重要。本文分析了目前国内外液体活检的相关仪器;介绍了“数字诊疗装备研发”国家重点专项“微流控器件-核酸质谱集成装备研制及在肿瘤精准医学中的应用解决方案”的研发情况。
Liquid biopsy can obtain information of tumorigenesis, metastasis and treatment by analyzing the expression and variation of circulating tumor cells (CTCs) and circulating tumor nucleic acids (ctDNAs) in peripheral blood and has broad application prospect in the accurate treatment of tumors . The development of effective CTC, ctDNA and microRNA detection instruments is particularly important. This paper analyzes the current domestic and international liquid biopsy related instruments; introduced “digital diagnosis and treatment equipment research and development ” national key project “microfluidic device - nucleic acid mass spectrometry integrated equipment development and application in cancer precision medicine solution ” R & D situation.