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通过不同的方法在脱氢枞胺中引入酰腙、没食子酸、肟、异烟基等对清除自由基有效果的基团,设计合成了几种新型的脱氢枞胺衍生物.利用1H NMR,13C NMR,IR和HRMS对所有合成的化合物进行了结构表征.测试了所合成的化合物对清除超氧阴离子(O2-)和二苯代苦味酰基自由基(DPPH·)的活性,其中N-(3,4,5-三羟基苯甲酰基)-脱氢枞胺(6)对O-2的抑制率达到38.18%,是常用抗氧化药物Vc(18.35%)的两倍以上;对(DPPH·)的半数抑制浓度为0.002×103 mg/L,远优于Vc(0.236×103 mg/L).
Several new dehydroabietylamine derivatives were designed and synthesized by different methods, such as acylhydrazone, gallic acid, oxime and isonicotinyl, which are effective to scavenging free radicals. Determined by 1H NMR , 13C NMR, IR and HRMS.All the synthesized compounds were characterized for their activity on scavenging superoxide anion (O2-) and dibenzyl picryl radical (DPPH ·), and the activity of N- (3,4,5-trihydroxybenzoyl) -dehydroabietylamine (6), the inhibitory rate of O-2 reached 38.18%, which was more than twice that of the commonly used antioxidant Vc (18.35% ·) Was 0.002 × 103 mg / L, much better than Vc (0.236 × 103 mg / L).