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本实验对４８例石蜡包埋人肝癌和癌旁组织的Ｐ~（５３）蛋白（突变型）和ＨＢｘＡｇ进行了免疫组化（ＡＢＣ法）检测。结果显示肝癌及其癌旁组织Ｐ~（５３）蛋白（突变型）和ＨＢｘＡｇ阳性率分别为２９．２％（１４／２８）和９３．８％（４５／１８），Ｐ~（５３）蛋白（突变型）与ＨＢｘＡｇ表达不相关（Ｐ＞０．０５），提示ＨＢｘＡｇ在Ｐ~（５３）基因突变中不发挥作用。
In this study, 48 cases of paraffin-embedded human liver cancer and paracancerous tissues were detected by immunohistochemistry (ABC). The results showed that the positive rates of P53 protein (mutant) and HBxAg in HCC and adjacent tissues were 29.2% (14/28) and 93.8% (45/18) respectively. P53 protein (Mutation type) was not associated with HBxAg expression (P>0.05), suggesting that HBxAg does not play a role in P53 mutation.