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目的 探讨食管癌患者的异常免疫状态下血清sTNFR1检测的临床意义。材料和方法 用双单抗夹心酶联免疫吸附法（ELISA）检测40例食管癌患者和30例正常人血清sTNFR1水平。结果 食管癌病人血清sTNFR1浓度[（129.45±42.54）U/ml]显著高于正常人[（51.64±26.67 U/ml），P<0.05]，且其升高程度与病变食管长度、病情轻重及有无恶液质有关。结论 sTNFR1的检测对食道癌的早期诊断和预后具有实用价值。
Objective To investigate the clinical significance of serum sTNFR1 detection in patients with esophageal cancer. Materials and Methods Serum sTNFR1 levels were detected in 40 patients with esophageal cancer and 30 normal controls by double enzyme sandwich enzyme-linked immunosorbent assay (ELISA). Results The serum concentration of sTNFR1 in esophageal cancer patients was significantly higher than that in normal controls (51.64±26.67 U/ml, P<0.05), and the degree of esophageal sTNFR1 elevation was related to the length and severity of esophageal disease. There is no relationship between viscous fluids. Conclusion The detection of sTNFR1 has practical value in the early diagnosis and prognosis of esophageal cancer.