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目的对直肠癌患者血清中白细胞介素-2（IL－2）和可溶性白细胞介素-2受体（SIL－2R）进行检测。方法对IL－2和SIL－2R的检测均采用ELISA双抗夹心法。结果直肠癌患者手术前和手术后10~20d血清中IL－2含量明显低于正常对照组，而SIL－2R含量则显著高于正常对照组。其手术前与术后10－20d血清中IL－2和SIL-2R表达相比较经统计学处理无明显差异。结论本研究提示，直肠癌患者采用IL－2等细胞因子进行辅助治疗，既可增强抗肿瘤免疫效应，又有利于患者的康复。
Objective To detect serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2R) in patients with rectal cancer. Methods The detection of IL-2 and SIL-2R were performed using ELISA double antibody sandwich method. Results The serum levels of IL-2 in patients with rectal cancer from 10 to 20 days before and after surgery were significantly lower than those in the normal control group, while the SIL-2R content was significantly higher than that in the normal control group. There was no significant difference in serum IL-2 and SIL-2R expressions before and after surgery from 10 to 20 days after treatment. Conclusions This study suggests that the use of IL-2 and other cytokines for adjuvant treatment of rectal cancer patients can enhance the anti-tumor immune effects, and it is also conducive to the rehabilitation of patients.