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呋喃硝胺(ranitidine)是一种新的 H_2受体拮抗剂,据报道用呋喃硝胺200mg/天短期治疗十二指肠溃疡,疗效与甲氰咪胍相仿。甲氰咪胍虽有显著的抗溃疡特性,但因能改变胃粘液成份,故停药后溃疡复发率明显增加。胃可溶性粘液的改变对十二指肠和胃粘膜的防御均有影响,十二指肠溃疡用甲氰咪胍治愈后,继以生胃酮作维持治疗,胃粘液可恢复正常,一旦停药时,十二指肠溃疡复发率亦相对降低。相反,用甲氰咪胍治愈后仍继续用甲氰咪胍作维持治疗者,病人胃粘液成分持续不正常,溃疡复发率显著增高。
Ranitidine is a new H 2 receptor antagonist. It has been reported that short-term treatment of duodenal ulcer with 200 mg nitrofuranton / day is similar to cimetidine. Although cimetidine guanidine significant anti-ulcer properties, but can change the gastric mucus composition, so the withdrawal rate after ulcer recurrence increased significantly. Gastric mucilage changes in duodenum and gastric mucosal defense are affected, duodenal ulcer cured with cimetidine, followed by carbaryl for maintenance therapy, gastric mucus can be returned to normal, once the withdrawal , The recurrence rate of duodenal ulcer is also relatively reduced. In contrast, with cimetidine cured cimetidine continue to maintain treatment, the patient’s gastric mucus continued to be abnormal, significantly increased the incidence of ulcer recurrence.