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[目的] 观察广东南海地区不同时间段急性胰腺炎(AP)病因谱的变化。[方法] 将 1980 年 1 月~1984年12月收治的96例AP患者和2000年1月~2004年12月收治的156例AP患者分为A组和B组,比较二组的病因差异。[结果] 同A组相比,B组酒精中毒所致的AP病例明显增多(45 5%∶30 2%,χ2=5 8,P<0 05);而胆道疾病所致的AP则显著下降(37 8%∶53 1%,χ2=5 7,P<0 05)。[结论] 酒精中毒已经成为近年来广东南海地区AP的主要病因。
[Objective] To observe the changes of etiology spectrum of acute pancreatitis (AP) in different periods of time in South China Sea in Guangdong. [Methods] A total of 96 AP patients admitted from January 1980 to December 1984 and 156 AP patients admitted from January 2000 to December 2004 were divided into group A and group B, and the etiological differences between the two groups were compared. [Results] Compared with group A, the number of AP caused by alcoholism in group B was significantly increased (45 5%: 302%, χ 2 = 58, P <0 05); while the AP induced by biliary disease was significantly decreased (37 8%: 53 1%, χ2 = 5 7, P <0 05). [Conclusion] Alcoholism has become the main cause of AP in the South China Sea in recent years.