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目的探讨硫辛酸、前列地尔与甲钴胺联合治疗糖尿病周围神经病变的临床疗效。方法 68例糖尿病周围神经病变患者作为研究对象,通过随机抽签方法分为治疗组与对照组,每组34例。治疗组应用硫辛酸、前列地尔与甲钴胺联合方案治疗,对照组应用甲钴胺联合前列地尔方案治疗。对比两组患者的治疗效果以及周围神经病变症状变化。结果治疗组患者的治疗总有效率为94.1%,高于对照组的70.6%,差异具有统计学意义(P<0.05)。治疗后治疗组平均国际通用SYDNEY神经病变主觉症状问卷(TSS)症状评分为(4.1±0.6)分,低于对照组的(7.5±0.9)分,差异具有统计学意义(P<0.05)。结论硫辛酸、前列地尔与甲钴胺联合治疗糖尿病周围神经病变的临床疗效肯定,并能有效纠正其周围神经病变症状,可推广。
Objective To investigate the clinical efficacy of lipoic acid, prostaglandin and mecobalamin in the treatment of diabetic peripheral neuropathy. Methods Sixty-eight patients with diabetic peripheral neuropathy were divided into treatment group (n = 34) and control group (n = 34) by random sampling. The treatment group was treated with lipoic acid, prostaglandin and mecobalamin, and the control group was treated with mecobalamin and alprostadil. The therapeutic effects of the two groups were compared with those of peripheral neuropathy. Results The total effective rate of treatment group was 94.1%, which was higher than that of control group (70.6%), the difference was statistically significant (P <0.05). After treatment, the symptom score of the international symptomatic SYDNEY neuropathy subjective symptom questionnaire (TSS) was (4.1 ± 0.6) in the treatment group, which was lower than that of the control group (7.5 ± 0.9), the difference was statistically significant (P <0.05). Conclusions The clinical efficacy of lipoic acid, prostaglandin and mecobalamin in the treatment of diabetic peripheral neuropathy is affirmative, and can effectively correct the symptoms of peripheral neuropathy and can be promoted.