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目的 探讨不同剂量甘露醇治疗高血压脑出血患者血清神经元特异性烯醇酶的变化及其意义。方法 97例高血压脑出血患者随机分为 2组 ,分别给予小剂量 (小剂量组 )和常规剂量 (常规剂量组 )甘露醇治疗 ,均于发病后第 1、3、7、14天测定其血清神经元特异性烯醇酶的浓度 ,比较两组患者同一天内测量值的变化。并与正常健康人进行对比。结果 两组患者起病后第 1、3、7天血清神经元特异性烯醇酶浓度较对照组显著升高 (P <0 .0 5 ) ,以第 3天最高。第 14天神经元特异性烯醇酶浓度与对照组比较无统计学差异(P >0 .0 5 )。两组间第 1、3、14天神经元特异性烯醇酶浓度比较均无显著差异 (P >0 .0 5 )。第 7天时小剂量组低于常规剂量组 (P <0 .0 5 )。结论 小剂量甘露醇治疗高血压脑出血可取得与常规量相同 ,甚至更好的疗效。
Objective To investigate the changes and significance of serum neuron-specific enolase in patients with hypertensive intracerebral hemorrhage under different doses of mannitol. Methods Ninety-seven patients with hypertensive intracerebral hemorrhage were randomly divided into two groups: low dose (low dose) and normal dose (normal dose) of mannitol, all of which were measured on the 1st, 3rd, 7th and 14th day after onset Serum neuron-specific enolase concentrations were compared between the two groups on the same day measurements. And compared with normal healthy people. Results Serum neuron-specific enolase concentrations were significantly increased (P <0.05) on day 1, day 3 and day 7 in both groups, with the highest on day 3. There was no significant difference in neuron-specific enolase concentration between the 14th day and the control group (P> 0.05). There was no significant difference in neuron-specific enolase concentrations between days 1, 3 and 14 (P> 0.05). On day 7, the low dose group was lower than the conventional dose group (P <0.05). Conclusion Small doses of mannitol for treatment of hypertensive intracerebral hemorrhage can be obtained with the same amount, or even better efficacy.