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目的探讨Survivin蛋白在喉鳞癌组织中的表达及其临床意义。方法采用免疫组织化学法分别检测2015年1月至2009年12月收治的50例喉鳞癌患者鳞癌组织、癌旁组织、正常喉黏膜组织中Survivin的表达水平,结合临床资料和随访资料分析其与临床病理特征的关系。结果喉鳞癌组织中Survivin的表达显著高于癌旁组织和正常喉黏膜组织。在喉癌组织中,Survivin的表达率在不同年龄、性别、原发部位中比较差异无统计学意义(P均>0.05);在TNM不同分期及不同分化级别中表达率也相近(P均>0.05)。反映Survivin表达强度的阳性指数(IP)分别随喉鳞癌TNM分期和分化级别的增高而上升,差异均有统计学意义(P均<0.05)。Survivin的表达率和表达张度在有无淋巴结转移与生存是否≥5年中比较差异均有统计学意义(P<0.05,P<0.01)。结论 Survivin可作为临床诊断喉鳞癌的重要参考指标之一,对判断喉鳞癌淋巴结转移及预后更具指导意义。
Objective To investigate the expression of Survivin protein in laryngeal squamous cell carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of Survivin in 50 cases of laryngeal squamous cell carcinoma, para-carcinoma tissue and normal laryngeal mucosa from January 2015 to December 2009, respectively. Combined with the clinical data and follow-up data Its relationship with clinicopathological features. Results The expression of Survivin in laryngeal squamous cell carcinoma tissues was significantly higher than that in paracancerous tissues and normal laryngeal mucosa tissues. In laryngeal carcinoma, the expression rate of Survivin was not significantly different at different age, sex and primary site (all P> 0.05), and the expression rates of Survivin in different stages and differentiated grades of TNM were also similar (P> 0.05). The positive index (IP), which reflects the expression intensity of Survivin, increased with the TNM staging and differentiation level of LSCC respectively, with statistical significance (P <0.05). The expression of Survivin and the expression of T lymph node metastasis and survival in ≥ 5 years were statistically significant (P <0.05, P <0.01). Conclusion Survivin can be used as one of the important reference indexes for the diagnosis of laryngeal squamous cell carcinoma, which is more instructive in judging the lymph node metastasis and prognosis of laryngeal squamous cell carcinoma.