肥胖基因（ｏｂｅｓｅｇｅｎｅ，ｏｂｇｅｎｅ）及其产物Ｌｅｐｔｉｎ在肥胖的发生中起重要作用，人们已定位克隆了ｏｂ基因并对ｏｂ基因及其调控序列、ｏｂ基因的产物及其功能，各种因素对ｏｂ基因及其产物表达的影响等方面作了深入研究，并提出了机体调节体重的可能途径。本文就以上几个方面作一综述。 Obese gene (obgene) and its product Leptin play an important role in the occurrence of obesity. The ob gene has been located and cloned, and the ob gene and its regulatory sequence, the ob gene product and its function, various factors on the ob gene And its product expression and other aspects of the impact made in-depth study, and put forward the body possible way to regulate body weight. This article gives a summary of the above aspects.