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目的:探讨急性肺栓塞患者中性粒细胞/淋巴细胞比值(NLR)、白细胞介素-6(IL-6)、血浆渗透压与CT肺动脉阻塞指数(PAOI)、简化急性肺栓塞严重程度指数(sPESI)的关系及其对预后的预测效能。方法:回顾性分析2015年5月至2020年5月安阳市第二人民医院收治的326例急性肺栓塞患者的临床资料，根据住院结局分为病死组(30例)和存活组(296例)。比较两组患者入院时一般资料、PAOI、sPESI评分；比较两组患者治疗前后NLR、IL-6、血浆渗透压；分析NLR、IL-6、血浆渗透压与PAOI、sPESI评分的相关性；评价NLR、IL-6、血浆渗透压对预后的预测价值。结果:病死组入院时血糖、PAOI、sPESI评分均高于存活组(n P均<0.05)；治疗前及治疗后12 、24 h，病死组NLR、IL-6、血浆渗透压均高于存活组(n P均<0.05)。治疗前及治疗后12、24 h，NLR、IL-6、血浆渗透压与PAOI、sPESI评分均呈正相关(n P均<0.05)。治疗前及治疗后12、24 h，NLR、IL-6、血浆渗透压在预测急性肺栓塞患者预后方面均具有良好效能，其中治疗后24 h NLR预测患者预后的曲线下面积最大，为0.868。n 结论:NLR、IL-6、血浆渗透压与急性肺栓塞患者PAOI、sPESI评分呈正相关，动态监测各指标水平可辅助临床预测患者预后情况。“,”Objective:To investigate the relationship of neutrophil lymphocyte ratio (NLR), interleukin-6 (IL-6), plasma osmotic pressure with CT pulmonary artery occlusion index (PAOI) and simplified acute pulmonary embolism severity index (sPESI), and the predictive value for prognosis in patients with acute pulmonary embolism .Methods:The clinical data of 326 patients with acute pulmonary embolism treated in Anyang Second People’s Hospital were retrospectively analyzed, and they were divided into death group (30 cases) and survival group (296 cases) according to the hospitalization outcome. The general data, PAOI and sPESI scores of the two groups were compared; NLR, IL-6 and plasma osmotic pressure before and after treatment were compared between the two groups. The correlation of NLR, IL-6, plasma osmotic pressure with PAOI and sPESI scores was analyzed, and the prognostic value of NLR, IL-6 and plasma osmotic pressure was evaluated.Results:The blood glucose level, PAOI and sPESI scores in the death group were higher than those in the survival group at the time of admission (all n P<0.05). Before treatment and 12, 24 hours after treatment, NLR, IL-6 and plasma osmotic pressure in the dead group were higher than those in the survival group (alln P<0.05). NLR, IL-6 and plasma vascular pressure were positively correlated with PAOI and sPESI scores before treatment and 12, 24 hours after treatment (alln P<0.05). Before treatment and 12, 24 hours after treatment, NLR, IL-6 and plasma osmotic pressure had good efficacy in predicting the prognosis of patients with acute pulmonary embolism. Among them, the area under the curve of NLR in predicting the prognosis of patients 24 hours after treatment was the largest, that was 0.868.n Conclusions:NLR, IL-6, plasma osmotic pressure are positively correlated with PAOI and sPESI scores in patients with acute pulmonary embolism. Dynamic monitoring of the levels of various indicators can help clinically predict the prognosis of patients.